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Epitope Identification and Modification for Reduced Allergenic Activity in Proteins Targeted for Transgenic Expression
Invention Reference: 04/MED/165
Disclosed is a method for identification of key amino acids in plant proteins critical in generating allergenic activity through mapping the epitope(s) harboring human IgE binding activity. The identified epitope(s) are then modified by amino acid substitution preferably by alanine substitution, for reduced or negative...
Inventor(s): Sai Ming Samuel Sun, Da Ming Chen
Keywords(s):
Category(s): Agriculture
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An Lysine-enriched Protein and Its Application on Breeding Transgenic Plant Seeds with Enhanced Nutritive Value
Invention Reference: 05/MED/206
High Lysine Rice
The present invention, taking advantage of the high efficiency of expression and packaging system of natural seed storage protein, provides a method to genetically engineer a fusion protein between a major seed storage protein and a target protein of high nutritional value so that its high level...
Inventor(s): Sai Ming Samuel Sun, Qian Quan Liu
Keywords(s):
Category(s): Agriculture
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A Novel Signal Transduction Gene Confers Disease Resistance
Invention Reference: 07/MED/254
Genes Against Biotic and Abiotic stresses
OsGAP1 –gene encoding a novel GTPase activation protein cloned from the monocot plant rice. Overexpression of this gene in rice and the dicot plant Arabidopsis thaliana enhances resistance toward bacterial pathogens.
GmRD22 – gene encoding an apoplastic...
Inventor(s): Hon Ming Lam, Sai Ming Samuel Sun
Keywords(s):
Category(s): Agriculture
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A Cost-effective Method for Expression and Purification of Recombinant Proteins in Plants
Invention Reference:10/MED/400
This invention provides a cost-effective and efficient method to express and purify recombinant proteins in transgenic plants.
The recombinant proteins are expressed as fusions with an elastin-like polypeptide (ELP)-intein tag and include pharmaceuticals, antibody chains and other useful proteins. They may be produced...
Inventor(s): Sai Ming Samuel Sun, Li Tian
Keywords(s):
Category(s): Agriculture
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Therapeutic Protein from the Traditional Chinese Medicine Yuzhu
Invention Reference: 04/MED/188
An isolated protein from the Chinese medicinal herb Yuzhu, Polygonatum odoratum (Liliaceae) that shows potent antiviral activities while demonstrating antiproliferative effect on HL-60 leukemia and MCF-7 breast cancer cell lines in vitro and the method of obtaining the protein.
Yuzhu (玉竹),...
Inventor(s): Shiou Mei Linda Ooi, Sai Ming Samuel Sun, Eng Choon Vincent OOI
Keywords(s):
Category(s): Therapeutics
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