Invention Reference: 11/MED/451
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We demonstrated that the activation of an epithelial ion channel can trigger signaling cascade leading to the release of PGE2, an important mediator of implantation and inflammation, and upregulation of cyclooxygenase 2 (COX-2), the enzyme important for prostaglandin (PG) production. Interfering with the ion channel function can suppress COX-2 and PG release and result in implantation failure in mice. |
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Abnormal channel expression is also found in IVF patients with implantation failure. Given the wide distribution of the ion channel and the importance of COX-2/PGs in implantation and inflammation, interfering with the channel function represents a new method for contraception and anti-inflammation.
